By Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)
Building at the latest titles within the "Airways tender Muscle" sub-series, the 6th quantity explores physiological and pharmacological strategies within the lung in vivo. some of the animal versions on hand for learning the bronchospasm and irritation linked to human bronchial asthma are completely reviewed through across the world known scientists. particular chapters specialise in the issues of administering medicines to animal airlines, the mechanics of assessing lung functionality within the versions, and describe intimately the species used, from rodents to primates. using genetically altered animals, a space of specific curiosity to molecular biologists, is additionally thought of extensive. This up to date and broadly referenced paintings will turn out priceless to pharmacologists, physiologists and different organic scientists in any respect degrees in academia and within the pharmaceutical industry.
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Extra resources for Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo
Unlike the Wright dust feed unit and the fluidized bed generator, the jet mill aerosol generator is efficient in dispersing soft, sticky materials . 4. Liposomes In the development of drugs such as bronchodilators and corticosteroids, which are intended for administration into the airways, efforts are made to maximize the duration of local action and reduce systemic effects. Liposomes have attracted attention since they can markedly alter the pharmacokinetics and pharmacodynamics of drugs. They offer a method for sustained drug release which ensures a prolonged therapeutic concentration of the drug in the lung after a single administration.
J Appl Physiol 1992; 73: 410-9. 45. EideIman DH, Bellofiore S, Martin JG. Late airway responses to antigen challenge in sensitized inbred rats. Am Rev Respir Dis 1988; 137; 1033-7. 46. Schiantarelli P, Bongrani S, Papotti M, Cadel S. Investigation of the activity of bronchodilators using a simple but accurate inhalation procedure: Forced inhalation. J Pharmacol Methods 1982; 8: 9-17. 50 S. L. Underwood and D. Raeburn 47. Underwood SL, Lingham D, Pearson J, Raeburn D. A nove1 technique for the administration of bronchodilator drugs formulated as dry powders to the anaesthetized guinea pig.
Influence of Respiratory Tract Fluid on Airway Calibre. In: Raeburn D, Giembycz MA, editors. Airways Smooth Muscle: Development and Regulation of Contractility. Basel: Birkhaüser, 1994: 291-305. 68. Kapanci Y, Assimacopoulos A, Irle C, Zwahlen A, Gabbiani G. Contractile interstitial cells in pulmonary alveolar septa: A possible regulator of ventilation/perfusion ratio. J Cell Biol 1974; 60: 375-92. 69. Miller WS. The musculature of the finer divisions of the bronchial tree and its relation to certain pathological conditions.